Dr. Mario 64

About

Dr. Mario 64 turns puzzle-solving into a cold-fighting crusade. Players guide Dr. Mario or Wario through levels filled with germs, using Megavitamin blocks to clear them by matching colors. Each move shifts the board like a 3D puzzle, with power-ups and hazards adding twists. The game mixes solo challenges and competitive play, letting up to four people battle simultaneously on one screen. Split-screen multiplayer remains the standout feature, offering chaotic, couch-friendly fun that’s held up over the years. While the story is light, the game’s fast-paced matches and character roster including Wario and Rudy the Clown keep it engaging. A cult hit among retro puzzle fans, it’s still praised for its addictive, no-frills design.